发明名称 |
PROCESS FOR THE PREPARATION OF NEOTAME |
摘要 |
The invention relates to an improved process for the preparation of neotame by successively: (a) subjecting a mixture of N-benzyloxycarbonyl-L-.alpha.- aspartyl-L-phenylalanine-1-methyl ester and 3,3-dimethylbutyraldehyde in solution to hydrogenation in a homogeneous methanolic solvent, in the presen ce of a hydrogenation catalyst; (b) separating the catalyst from the solution a s a solid substance; (c) removing a portion, at least, of the organic part of the solvent through evaporation and optionally adding an amount of water before and/or during and/or after that evaporation and (d) separating the solid neotame formed, optionally after cooling of the system thus obtained, from the remaining liquid and drying it. |
申请公布号 |
CA2343114(A1) |
申请公布日期 |
2000.03.23 |
申请号 |
CA19992343114 |
申请日期 |
1999.09.07 |
申请人 |
HOLLAND SWEETENER COMPANY V.O.F. |
发明人 |
TEUNISSEN, ANTONIUS JACOBUS JOSEPHUS MARIA;QUAEDFLIEG, PETER JAN LEONARD MARIO;SNIJDER, CARINA SASCHA;BOESTEN, WILHELMUS HUBERTUS JOSEPH |
分类号 |
A23L27/30;C07B61/00;C07K5/072;C07K5/075 |
主分类号 |
A23L27/30 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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