| 摘要 |
PROBLEM TO BE SOLVED: To obtain a medicine composition comprising a specific propiophenone derivative as an active ingredient, having excellent urine sugar increasing action based on glucose resorption inhibition in the kidney, showing excellent blood sugar lowering action, forming its aglycon showing extremely weak inhibitory action on a sugar transporting carrier of facilitated diffusion type. SOLUTION: This medicine composition contains a propiophenone derivative of the formula [OH is a (protected) OH; Y is a lower alkyl; Z is a (protected)β-D-glucopyranosyl]propiophenone, preferably 3-(5-benzo[b]furanyl)-2'-(β-D- gluconopyranosyloxy)-6'-hydroxy-4'-methylpropiophenone or its pharmacologically acceptable salt (e.g. sodium salt, etc.), as an active ingredient. The compound of the formula can be made into a preparation by using a medicine carrier (e.g. binder, excipient, etc.). Preferably the daily dose of the compound of the formula is 0.5-15 mg/kg in the case of oral administration and 0.05-3 mg/kg in the case of parenteral administration.
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