| 摘要 |
PROBLEM TO BE SOLVED: To obtain a matrix metalloprotease production inhibitor capable of inhibiting the production of matrix metalloprotease or its precursor, useful as a preventive and/or a therapeutic agent for chronic rheumatism, arthrosis deformans, cancer, etc., by making the inhibitor include a specific polyalkoxyflavonoid. SOLUTION: This inhibitor contains a polyalkoxyflavonoid of the formula (R1 is H or a 1-6C alkyl; R2 to R4 are each H or a 1-6C alkoxy; R5 is a 1-6C alkyl) (preferably 5-demethylnobiletin, tangeretin, nobiletin, etc.). The inhibitor inhibits preferably the production of an enzyme of collagenase group, an enzyme of gelatinase group, an enzyme of stromelysin group, etc. The dose of the inhibitor is generally 100-1,000 mg calculated as the amount of flavonoid being an active ingredient and the inhibitor is administered once to several times daily. |
