摘要 |
A pyrimidine derivative of formula (I) wherein, for example, R<SUP>1 </SUP>is hydrogen, (1-6C)alkyl, (3-5C)alkenyl or (3-5C)alkynyl; Q<SUB>1 </SUB>and Q<SUB>2 </SUB>are independently selected from phenyl, naphthyl, indanyl and 1,2,3,4-tetrahydronaphthyl; and one or both of Q<SUB>1 </SUB>and Q<SUB>2 </SUB>bears on any available carbon atom one substituent of formula (Ia) [provided that when present in Q<SUB>1 </SUB>the substituent of formula (Ia) is not adjacent to the -NH- link]; wherein, for example, X is CH<SUB>2</SUB>, O, S or NH; Y is H or as defined for Z; Z is OH, SH, NH<SUB>2</SUB>, (1-4C)alkoxy, (1-4C)alkylthio, -NH(1-4C)alkyl, -N[(1-4C)alkyl]<SUB>2 </SUB>or -NH-(3-8C)cycloalkyl; n is 1, 2 or 3; m is 1, 2 or 3; and Q<SUB>1 </SUB>and Q<SUB>2 </SUB>may optionally bear other substituents selected, for example, from halogeno, (1-6C)alkyl, cyano and (2-4C)alkenyl; or a pharmaceutically-acceptable salt or in-vivo-hydrolysable ester thereof; are useful as anti-cancer agents; and processes for heir manufacture and pharmaceutical compositions containing them are described. |