发明名称 |
Pharmaceutical composition for combination of piperidinoalkanol-decongestant |
摘要 |
The present invention provides a pharmaceutical composition in the form of a bilayer tablet comprising, (a) a first discrete zone made with Formulation (A) which comprises, a therapeutically effective decongestant amount of a sympathomimetic drug, or a pharmaceutically acceptable salt thereof, in an amount of about 18% to about 39% by weight of Formulation (A), and a first carrier base material, the first carrier base material comprising a mixture of; (I) carnauba wax in an amount of about 59% to about 81% by weight of Formulation (A); and (ii) a suitable antiadherent in an amount of about 0.25% to about 2.00% by weight of Formulation (A); wherein said first carrier base material provides a sustained release of the sympathomimetic drug; and (b) a second discrete zone made with Formulation (B) which comprises a therapeutically effective antihistaminic amount of a piperidinoalkanol, or a pharmaceutically acceptable salt thereof, in an amount of about 15% to about 30% by weight of Formulation (B) and a second carrier base material, the second carrier base comprising a mixture of; (I) a cellulose diluent in an amount of about 27% to about 73% by weight of Formulation (B); (ii) pregelatinized starch in an amount of about 15% to about 30% by weight of Formulation (B); (iii) a suitable disintegrant in an amount of about 0.25% to about 6.00% by weight of Formulation (B); and (iv) a suitable lubricant in an amount of about 0.25% to about 2.00% by weight of Formulation (B); wherein said second carrier base material provides an immediate release of the piperidinoalkanol or the pharmaceutically acceptable salt thereof.
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申请公布号 |
US6039974(A) |
申请公布日期 |
2000.03.21 |
申请号 |
US19980127478 |
申请日期 |
1998.07.31 |
申请人 |
HOECHST MARION ROUSSEL, INC. |
发明人 |
MACLAREN, DAVID D.;LEFLER, JOHN R.;MINISH, SHARON K. |
分类号 |
A61K9/20;A61K9/22;A61K9/24;A61K31/445;A61K45/00;A61K45/06;A61K47/04;A61K47/12;A61K47/38;A61K47/44;A61P11/02;A61P11/08;A61P37/08;A61P43/00;(IPC1-7):A61K9/22;A61K9/28 |
主分类号 |
A61K9/20 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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