发明名称 |
Inducible expression system |
摘要 |
The invention concerns an inducible expression system using nucleotide sequences coding for a transcriptional activator of eukaryotic or viral origin and a recombinant adenoviral vector comprising a gene of interest placed under the control of a promoter inducible in trans by said transcriptional activator. The invention also concerns a recombinant adenoviral vector bearing a first expression cassette coding for a transcriptional activator and a second cassette bearing a gene of interest placed under the control of a promoter inducible in trans by said transcriptional activator. The invention further concerns an infectious viral particle, its preparation method, a eukaryotic cell and a pharmaceutical composition comprising such a vector or expression system as well as their use for therapeutic or prophylactic purposes. |
申请公布号 |
AU5426299(A) |
申请公布日期 |
2000.03.21 |
申请号 |
AU19990054262 |
申请日期 |
1999.08.27 |
申请人 |
TRANSGENE S.A. |
发明人 |
MAJID MEHTALI;TANIA SORG-GUSS |
分类号 |
C12N15/09;A61K35/76;A61K38/00;A61K48/00;A61P3/10;A61P7/04;A61P9/00;A61P9/08;A61P31/00;A61P31/04;A61P31/12;A61P31/18;A61P35/00;A61P43/00;C12N1/15;C12N1/19;C12N5/10;C12N7/00;C12N15/861 |
主分类号 |
C12N15/09 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|