Synthesis and use of amino acid fluorides as peptide coupling reagent

摘要

The present invention is directed to a process for forming a peptide bond between a first amino acid having a free amino group and a protected carboxy group and a second amino acid or between a peptide having a free amino group and a blocking carboxy group with a second amino acid which comprises (a) reacting the second amino acid of the formula: with a fluoroformamidinium salt of the formula: and (b) reacting the product of (a) with the first amino acid or peptide.