| 摘要 |
Described are preferred processes for producing 2-piperidineethanol compounds by hydrogenation of corresponding 2-pyridineethanol compounds. The preferred processes are conducted in the presence of an amine other than said reactant or product, and a hydrogenation catalyst preferably comprising a noble metal catalyst such as ruthenium or palladium or oxides thereof loaded to a high level in the system. The catalyst is preferably provided on a heterogeneous support, and most preferred processes are conducted using both controlled temperature conditions and high levels of catalyst to minimize the formation of deleterious byproducts. |
