摘要 |
Benzoxazine derivative of the formula (I) in which, R<1> is hydrogen, or a substituent, R<2> and R<3> each independently are hydrogen or C1-6 alkyl, R<4> is C1-6 alkyl, C3-6 cycloalkyl, phenyl, C(=Y<1>)Z<1>R<8> or C(=Y<1>)R<8>, n is 0 or an integer of 1 to four, W is C=O or -CH2-, X is -CONH-, -CH2NH-, -NHCONH- or -SO2NH-, Y is substituted or unsubstituted aryl or heterocyclyl and pharmaceutically acceptable salts thereof are useful as active ingredients for pharmaceutical compositions for curing cardiac insufficiency. |