| 摘要 |
FIELD: organic chemistry, virology, pharmacy. SUBSTANCE: invention describes the novel compound - sulfonylalkanoylamino-hydroxyethylamino-sulfonamide compound of the general formula (I) <EMI ID=0.1 HE=28 WI=83 TI=CHI> where R means alkyl; R1, R20, R21 mean independently hydrogen atom or alkyl; R2 means alkyl or aralkyl; R3 means alkyl; R4 means aryl that is optionally substituted with one or some substituents taken among the group involving alkyl, alkoxy-, hydroxy-, amino-, acetamino-group; or benzothiazole, benzodioxyolyl, benzofuryl, benzimidazolyl, benzodioxanyl; R6 means hydrogen atom; Y means oxygen atom; x = 2; t = 0 or 1, or its pharmaceutically acceptable salts. Compounds are effective antiviral agents, especially, against retroviral infections. In part, they are effective inhibitors of HIV-infection and can inhibit other retroviruses, for example, lentiviruses, other HIV-virus strains, leukemia virus of human T-cells and so on. EFFECT: enhanced antiviral activity of compounds. 34 cl, 11 tbl, 24 ex
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