PHYSICAL FORM OF (R)-7-ACETYL-5-(4-AMINOPHENYL)-8,9-DIHYDRO- -8-METHYL-7H-1,3-DIOXOLO[4,5-H]-[2,3]-BENZODIAZEPINE, METHOD OF ITS SYNTHESIS AND PHARMACEUTICAL COMPOSITION

摘要

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to physical form of (R)-7-acetyl-5-(4-aminophenyl)-8,9-dihydro- -8-methyl-7H-1,3-dioxolo[4,5-h]-[2,3]-benzodiazepine exhibiting powder roentgenogram eliciting d parameters at 10.61; 8.83; 6.78; 5.83; 4.13 and 3.78 <EMI ID=0.1 HE=6 WI=2 TI=CHI> and showing strong and selective antagonist effect on AMPA--receptors. EFFECT: improved method of synthesis, valuable pharmacological properties. 4 cl, 1 tbl, 24 ex