RECOMBINANT HUMAN SM-11044-BINDING RECEPTOR PROTEIN HAVING ACTIVITY OF BINDING TO LIGAND AND UTILIZATION THEREOF

摘要

Transformed cells wherein a recombinant human SMBP is expressed at such a high level as enabling the assay of the ligand-binding activity by deleting the polythymidine sequence from the base sequence of the 3'-nontranslation region or the cell membrane fraction thereof; the recombinant human SMBP isolated from these transformed cells or the cell membrane fraction thereof; a method for screening a human SMBP agonist/antagonist characterized by using the above transformed cells, the cell membrane fraction thereof or the isolated recombinant human SMBP; and the human SMBP agonist/antagonist, etc. obtained by the above screening method.