发明名称 |
EXTENDED RELEASE ACETAMINOPHEN |
摘要 |
An extended release acetaminophen composition comprises particles containing acetaminophen coated on sugar/starch seeds. The particles are present as a blend of both an immediate release and a controlled release form. The composition, when contained within a gelatin capsule and assayed in a USP Apparatus I rotating basket at 50 rpm in 900 mL of phosphate buffer at pH 5.8 and a temperature of 37 DEG C, exhibits about 40 percent acetaminophen dissolution at one-half hour, about 55 percent acetaminophen dissolution at one hour, and substantially complete dissolution of acetaminophen at six hours. A process for treating a human patient with the extended release acetaminophen composition is also disclosed.
|
申请公布号 |
WO0013670(A1) |
申请公布日期 |
2000.03.16 |
申请号 |
WO1999US20381 |
申请日期 |
1999.09.03 |
申请人 |
ASCENT PEDIATRICS, INC. |
发明人 |
ANAEBONAM, ALOYSIUS, O.;CLEMENTE, EMMETT;MENDES, ROBERT, W. |
分类号 |
A61K9/16;A61K9/50;A61K9/54;(IPC1-7):A61K9/16 |
主分类号 |
A61K9/16 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|