PHOTORESPONSIVE NUCLEOSIDES AND PHOSPHORAMIDITES

摘要

Photoresponsive substances for introducing photoresponsive nucleosides into strands of DNA without structural freedom and easily. Specifically, nucleic acids bearing photoresponsive groups linked thereto by triple bonds or reactive derivatives of the same, preferably nucleic acids substituted with groups represented by general formula (I), (wherein R is hydrogen or cyano) or reactive derivatives of the same; nucleic acid oligomers containing the above nucleic acids; phosphoramidite reagents comprising phosphoramidite derivatives of the above nucleic acids; and a process for the preparation of nucleic acid oligomers by using the phosphoramidite reagents.