发明名称 |
PROMOTING NITRIC OXIDE AND CYCLIC GMP ACTIVITY |
摘要 |
Methods and compositions for promoting nitric oxide (NO) and/or cGMP activity in a subject. A precursor for nitric oxide, such as arginine, is orally administered together with an agonist for NO, including thioamino acids, substituted mono or polyphenol antioxidants and plant extracts that promote endothelium-dependent relaxation, to synergistically enhance NO activity and thereby cGMP activity. cGMP activity is further enhanced by concomitant administration of phosphodiesterase inhibitor, including inhibitors specific to type V phosphodiesterase, such as sildenafil, and non-specific inhibitors, particularly xanthines, such as theobromine. The formulations are used in the treatment of NO and/or cGMP insufficiency, and particularly conditions involving the cardiovascular, pulmonary and reproductive systems, such as erectile dysfunction or deficiency in luetenizing hormone releasing hormone.
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申请公布号 |
WO0000212(A8) |
申请公布日期 |
2000.03.16 |
申请号 |
WO1999US13893 |
申请日期 |
1999.06.22 |
申请人 |
NUTRACORP SCIENTIFIC, INC.;SHELL, WILLIAM, E.;JARMEL, MARK, E. |
发明人 |
SHELL, WILLIAM, E.;JARMEL, MARK, E. |
分类号 |
A61K31/195;A61K31/35;A61K36/45;A61K36/48;A61K36/53;A61K36/54;A61K36/61;A61K36/73;A61K36/736;A61K36/81;A61K36/82;A61K36/87;A61K36/899;(IPC1-7):A61K35/78 |
主分类号 |
A61K31/195 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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