Oxygenator membrane for use e.g. in heart operations, obtained by hydrolytic condensation of mixture containing organosilane with polymerizable double bonds, then processing as film and hardening, e.g. by irradiation

摘要

Oxygenator membranes are produced by processing a liquid obtained by hydrolytic condensation of hydrolyzable organo-silanes with polymerizable unsaturated groups and/or hydrolyzable organo-silanes with other functions such as mercapto groups and then hardening the resulting film. Oxygenator membranes, obtained by processing a slightly viscous to resinous liquid to form a membrane which is optionally dried and then subjected to thermal and/or radiation-induced and/or chemically-induced hardening. The liquid used is obtained (a) by hydrolytic polycondensation of compound(s) of formula (I) and/or (II) and/or (III) and/or (IV) and/or from precondensates derived from (I)-(IV) and optionally from compounds of formula (V) and/or precondensates derived from these, carried out by addition of water or moisture, in the presence or absence of solvent and/or condensation catalyst, using a mol ratio of (I + II + III + IV):(V) = (1:0)-(1:20), and optionally (b) with the addition of monomer(s) and/or oligomer(s) which is/are copolymerisable and/or suitable for (poly)addition reactions and/or with the addition of hardening catalyst(s). R = 1-15C alkyl, alkenyl, aryl, alkaryl or aralkyl, optionally containing oxygen or sulfur atoms and/or ester, carbonyl, carboxyl, amine and/or amino groups; R<1>, R<2> = 0-15C alkylene, arylene, arylene-alkylene or alkylene-arylene, all optionally modified as for R; R<3> = H, -R<2>-R<1>-R<4>-SiXxR3-x, carboxyl or a group R as defined above; R<4> = -(CHR<6>CHR<6>)n-, -CHR<6>CHR<6>-S-R<5>-, -CO-S-R<5>-, -CHR<6>CHR<6>-NR<6>-R<5>-, -Y-CS-NH-R<5>-, -S-R<5>-, -Y-CONH-R<5>-, -COOR<5>-, -Y-CO-C2H3(COOH)-R<5>-, -Y-CO-C2H3(OH)-R<5>- or -CO-NR<6>-R<5>-; R<5> = as for R<1> and R<2>, but with 1-15C atoms; R<6> = H, or 1-10C alkyl or aryl; R<7> = H or a group as defined for R; X = H, halogen, hydroxy, alkoxy, acyloxy, alkylcarbonyl, alkoxycarbonyl or NR2; R = H, alkyl or aryl; Y = -O-. -S- or -NR<6>-; Z = -O- or -(CHR<6>)m-; m = 1 or 2; a = 1, 2 or 3, with b = 1 for a = 2 or 3; b = 1, 2 or 3, with a = 1 for b = 2 or 3; c = 1-6; x = 1, 2 or 3; (a+x) = 2, 3 or 4. In (II), B = a 4-50C linear or branched organic residue with at least one C=C double bond; R = as in (I); R<3> = 0-10C alkylene, arylene, arylene-alkylene or alkylene-arylene, optionally with in-chain O, S or amino groups; X = as in (I), but with R = H, alkyl, aryl or alkylaryl; A = (a) O, S or NH for d = 1, Z = CO, R<1> = 1-10C alkylene, arylene or alkylene-arylene (optionally with in-chain O, S or amino) and R<2> = COOH or H, or (b) O, S, NH or COO for d = 1, Z = CHR' (with R' = H, alkyl, aryl or aralkyl), R<1> as in (a) and R<2> = OH, or (c) O, S, NH or COO for d = 0, R<1> as in (a) and R<2> = OH, or (d) S, for d = 1, Z = CO, R<1> = N and R<2> = H; a = 1, 2 or 3; b = 0, 1 or 2; (a+b) = 3; c = 1, 2, 3 or 4. ((HS-R<5>)nR<6>-S-E-R<5>)aSixR4-a-x (IV') A = O, S, PR, POR, NHCOO or NHCONR; B = a linear or branched organic residue derived from a 5-50C compound B' with at least one C=C double bond (if c = 1 and A = NHCOO or NHCONR) or at least two C=C bonds; R = as in (I); R' = alkylene, arylene or alkylene-arylene; R = H, alkyl, aryl or alkylaryl; X = as in (II); a = 1, 2 or 3; b = 0, 1 or 2; c = 0 or 1; x = a whole number, the value of which equals the number of double bonds in compound B' minus 1 or the number of double bonds in B', if c = 1 and A = NHCOO or NHCONR; alkyl/alkenyl = optionally substituted 1- or 2-20C linear, branched or cyclic groups; aryl = optionally substituted phenyl, naphthyl or biphenyl; other groups (alkoxy, acyloxy, alkylcarbonyl, alkoxycarbonyl, alkylaryl, aralkyl, arylene, alkylene and alkylene-aryl) = groups derived from alkyl and aryl groups as defined above . In (IV), R = as in (I); X = as in (II); Y = an organic residue with 1-30 (preferably 1-20) C atoms and 1-5 (preferably 1-4) mercapto groups; a, x = 1, 2 or 3; (a+x) = 2, 3 or 4 . In (V), R = as in (I); X = as in (II); a = 1, 2 or 3. An Independent claim is also included for a process for the production of oxygenator membranes by preparation of a slightly viscous to resinous liquid as described above, followed by processing by conventional methods to form a membrane which is optionally dried and then hardened as above.