Method of producing pyrrolidine derivatives

摘要

A method for producing pyrrolidine derivatives such as 3,4-epoxypyrrolodines and 3-pyrrolidols comprises oxidizing 3-pyrrolines with at least one peroxide in the presence of at least one acid. The 3-pyrrolines are obtainable by deriving cis-2-butene compounds from cis-2-butene-1,4-diols and performing a cyclization between the cis-2-butene derivatives and at least one primary amine. The method may be performed as a one-pot synthesis and may be performed as a continuous reaction.