发明名称 |
New hydroxy derivatives of tylosin and process for their preparation |
摘要 |
<p>The present invention relates to 12, 13-dihydroxy derivatives of tylosin, new semisynthetic compounds of the macrolide class, and to a process for their preparation. According to the present invention by the oxidation of 13-hydroxy derivative a 12,13-dihydroxy compound is obtained, which can be subsequently subjected to a series of reactions such as oximation, reduction (catalytic, electrochemical) or hydrolysis yielding corresponding dihydro or tetrahydro 12,13-dihydroxy derivatives.</p> |
申请公布号 |
EP0985679(A1) |
申请公布日期 |
2000.03.15 |
申请号 |
EP19990117654 |
申请日期 |
1999.09.07 |
申请人 |
PLIVA FARMACEUTSKA, KEMIJSKA, PREHRAMBENA |
发明人 |
NARANDJA, AMALIJA;LOPOTAR, NEVENKA;MANDIC, ZORAN |
分类号 |
A61K31/7048;A61P31/04;C07H17/08;(IPC1-7):C07H17/08 |
主分类号 |
A61K31/7048 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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