HIGH YIELD STEREOSPECIFIC MANNOSYLATION

摘要

PURPOSE: Published methodology for the malformation leads to difficulties in driving the reaction to completion, and frequently result in contamination with 1 to 3% of the beta anomer and ortho by-products. CONSTITUTION: Process of malformation begins with an alcohol or phenol along with a protected mannosyl fluoride. The alcohol or phenol is treated with the protected mannosyl fluoride in the presence of a Lewis acid to give the alpha-mannosylated product in high chemical yield and purity.