Role of human kis (hkis) as an inhibitory kinase of the cyclin-dependent kinase inhibitor p27. compositions, methods and uses thereof to control cell proliferation

摘要

Disclosed herein are novel composition and methods for altering the proliferation of a cell. Included are wild-type and mutant hKIS polypeptides along with cyclin kinase inhibitors containing mutations that prevent their inhibition with serine/threonine kinases.