Fluorogenic substrates for diagnosis and photodynamic treatment of tumors

摘要

PCT No. PCT/EP96/03201 Sec. 371 Date May 11, 1998 Sec. 102(e) Date May 11, 1998 PCT Filed Jul. 19, 1996 PCT Pub. No. WO97/03697 PCT Pub. Date Feb. 6, 1997Fluorogenic substrates susceptible of fluorescence emission and photosensitization by enzyme transformation suitable for diagnosis and photodynamic treatment of tumors, consisting of fluorescent substances with photosensitization activity, chemically modified with a group quenching the fluorescence and photosensitization properties, the said quencher group being removable by the cell enzyme activity with restoration of the properties of fluorescence and photosensitization activity of the original substance.