M-CSF MONOCLONAL ANTIBODIES THAT RECOGNIZE A NEUTRALIZING CONFORMATIONAL EPITOPE

摘要

Monoclonal antibodies are described, and methods of using the same, that bind to an apparent conformational epitope associated with recombinant or native dimeric M-CSF with concomitant neutralization of biological activity, which monoclonal antibodies are substantially unreactive with biologically inactive forms of MCSF including monomeric and chemically derivatized dimeric M-CSF.