发明名称 |
Preventing airway mucus production by administration of egf-r antagonists |
摘要 |
Hypersecretion of mucus in the lungs is inhibited by the administration of an epidermal growth factor receptor (EGF-R) antagonist. The EGF-R antagonist may be in the form of a small organic molecule, an antibody or portion of an antibody that binds to and blocks the EGF receptor. The EGF-R antagonist is preferably administered by injection in an amount sufficient to inhibit formation of goblet cells in pulmonary airways. The de-granulation of goblet cells that results in airway mucus production is thereby inhibited. Assays for screening candidate agents that inhibit goblet cell proliferation are also provided. |
申请公布号 |
AU5676699(A) |
申请公布日期 |
2000.03.14 |
申请号 |
AU19990056766 |
申请日期 |
1999.08.17 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, |
发明人 |
JAY A NADEL;KIYOSHI TAKEYAMA |
分类号 |
A01K67/027;A61K9/08;A61K9/10;A61K9/127;A61K9/72;A61K31/00;A61K31/711;A61K39/395;A61K45/00;A61K48/00;A61P11/00;A61P11/02;A61P11/06;A61P11/08;A61P11/10;A61P37/00;A61P39/00;A61P43/00;C12N5/00;C12N15/09;C12Q1/02;G01N33/50 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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