发明名称 |
Interactions between RaF proto-oncogenes and CDC25 phosphatases, and uses related thereto |
摘要 |
The present invention derives from the discovery that CDC25 phosphatases and Raf proteins are able to physically interact to form protein-protein complexes, with the Raf protein mediating the activation of CDC25 phosphatases. The present invention provides both cell-free and cellular assays for detecting agents which modulate the ras-dependent activation of CDC25, as for example, by affecting the binding of a CDC25 protein with Raf, or Raf-associated complexes. Also disclosed is a method for transforming/immortalizing cells, particularly primary cell cultures.
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申请公布号 |
US6037136(A) |
申请公布日期 |
2000.03.14 |
申请号 |
US19940328239 |
申请日期 |
1994.10.24 |
申请人 |
COLD SPRING HARBOR LABORATORY |
发明人 |
BEACH, DAVID H.;GALAKTIONOV, KONSTANTIN;JESSUS, CATHERINE |
分类号 |
C12Q1/42;(IPC1-7):G01N33/573 |
主分类号 |
C12Q1/42 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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