发明名称 |
Humanized anti-CD11a antibodies |
摘要 |
Humanized anti-CD11a antibodies and various uses therefor are disclosed. The humanized anti-CD11a antibody may bind specifically to human CD11a I-domain, have an IC50(nM) value of no more than about 1 nM for preventing adhesion of Jurkat cells to normal human epidermal keratinocytes expressing ICAM-1, and/or an IC50 (nM) value of no more than about 1 nM in the mixed lymphocyte response assay.
|
申请公布号 |
US6037454(A) |
申请公布日期 |
2000.03.14 |
申请号 |
US19970974899 |
申请日期 |
1997.11.20 |
申请人 |
GENENTECH, INC. |
发明人 |
JARDIEU, PAULA M.;PRESTA, LEONARD G. |
分类号 |
A61K39/395;C07K16/28;C12P21/08;(IPC1-7):C12P21/08;C07H21/04;C12N15/13 |
主分类号 |
A61K39/395 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|