发明名称 |
Diastereomeric pure trifluoromethyl ketone peptide derivatives as inhibitors of human leukocyte elastase |
摘要 |
The present invention relates to pyrrolidine derivative compounds, and more particularly to the compound (S)-1-[(S)-2-(4-methoxybenzamido)-3-methylbutyryl]-N-[(S)-2-methyl-1-(trifluoroacetyl)propyl]pyrrolidine-2-carboxamide, shown by the formula I, a pharmaceutical composition comprising this compound in a crystalline form and a process for preparing the pharmaceutical composition. The compound of formula I is an inhibitor of human neutrophil elastase and is useful in the treatment of diseases in which the enzyme is implicated, such as, for example, emphysema and acute respiratory distress syndrome (ARDS).
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申请公布号 |
US6037363(A) |
申请公布日期 |
2000.03.14 |
申请号 |
US19990253659 |
申请日期 |
1999.02.22 |
申请人 |
ZENECA LIMITED |
发明人 |
PEGG, STEPHEN JOHN;SEPENDA, GEORGE JOSEPH;DAVIES, ELWYN PETER;VEALE, CHRIS ALLAN |
分类号 |
A61K38/00;A61K;A61P9/00;A61P11/00;A61P29/00;C07K;C07K1/02;C07K5/06;C07K5/062;C07K5/083;(IPC1-7):A61K31/40;C07D207/12 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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