| 摘要 |
FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to derivatives of benzimidazole of the formula (I) HT1Dalpha where <EMI ID=0.1 HE=33 WI=75 TI=CHI> - H, R1, R7-alkyl, C1-6-alkoxy-group; C1-6 - H, R2, R3, R6, R11, R12-alkyl; C1-6 - H or halogen atom; m, p each = 0, 1 or 2; n = 2; Z means R4, R5, -O-, -S-, <EMI ID=0.2 HE=10 WI=10 TI=CHI>; <EMI ID=0.3 HE=10 WI=16 TI=CHI> - H, R9, R10-alkyl or phenyl-C1-6-alkyl; X - oxygen atom; Y means the residue of the formula (a) C1-6 or (b) <EMI ID=0.4 HE=20 WI=16 TI=CHI>; - H; their salts or solvates showing activity with respect to serotonin 5-<EMI ID=0.5 HE=20 WI=16 TI=CHI>-receptors and can be used for treatment of patients with obesity, bulimia, alcoholism, pains, depression. EFFECT: improved method of synthesis, valuable pharmacological properties. 8 cl, 12 ex
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