3', 3'-N-BIS-DESMETHYL-3'-N-CYCLOALKYL ERYTHROMYCIN DERIVATIVES AS LHRH ANTAGONISTS

摘要

Disclosed are 3',3'N-bis-desmethyl-3'-N-cycloalkyl-6-O-methyl-11-deoxy-11,12-cyclic carbamate erythromycin A derivatives of formula (I) which are antagonists of lutenizing hormone releasing hormone (LHRH). Also disclosed are pharmaceutical compositions comprising the compounds, to methods of using the compounds and to the process of making the same.