| 摘要 |
<p>The present invention provides an eukaryotic expression vector comprising the Guanylate Binding Protein 1 (GBP-1) gene or parts thereof. The introduction of said vector comprising said gene or parts thereof in sense or antinsense orientation into cells can be used to induce phenotypical changes of said cells and can, thus, be used for modulation of cell differentiation. Additionally, the present invention provides said vector for the treatment of cancer, sarcoma, lymphoma, hemangioma, artherosclerosis or restenosis, but also the treatment of inflammatory diseases like chronic ulcerative diseases, psoriasis, insect bites, freezing or burning injuries, wound healing or Morbus Crohn. Furthermore, the present invention provides, inter alia, a method for determination of the stage of cellular differentiation by using GBP-1 gene expression as a marker.</p> |
