POLYAMIDE CHAINS OF PRECISE LENGTH, METHODS TO MANUFACTURE THEM AND THEIR CONJUGATES WITH PROTEINS

摘要

Provided are chains of precise length and methods for their preparation. The se chains are formed by the reaction of a derivative of a diacid and a diamine in a stepwise manner on a support. One of the reactants contains a water solubl e oligomer, preferably polyethylene glycol. These chains are then used to chemically modify target macromolecules such as biologically important polypeptides.