| 摘要 |
Methods of isolating .beta.(1,3)-glucan or .beta.(1,3)-glucan-containing organisms in a sample, or of detecting the presence of .beta.(1,3)-glucan or .beta.(1,3)-glucan-containing organisms in a sample, utilizing a proteinaceo us receptor for underivatized, aqueous soluble .beta.(1,3)-glucan (e.g., an NR8383 receptor) are described. Methods of diagnosing fungal infection, by detecting .beta.(1,3)-glucan or .beta.(1,3)-glucan-containing organisms, are also described. Antibodies and kits useful in the methods are also disclosed . A preparation containing a proteinaceous receptor for underivatized, aqueous soluble .beta.(1,3)-glucan is additionally disclosed, along with characterization of the receptor for underivatized, aqueous soluble .beta.(1,3)-glucan. Also described are assays for identifying agents which alter the effect of underivatized, aqueous soluble .beta.(1,3)-glucan on activation of signal transduction pathways and agents identified thereby.</S DOAB>
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