6-FLUOROBICYCLO[3. 1.0]HEXANE DERIVATIVES

摘要

Fluorobicyclo[3.1.0]hexane derivatives represented by general formula (I), pharmaceutically acceptable salts thereof or hydrates of the same wherein R<1> and R<2> represent each hydrogen, alkyl, cycloalkyl, etc.; and Y<1> and Y<2> represent each hydrogen, alkylthio, cycloalkylthio, alkoxy, etc., or one of Y<1> and Y<2> represents hydrogen and the other represents hydroxy, alkoxy, cycloalkoxy, etc., or Y<1> and Y<2> together represent oxygen or -X(CH2)nX- (wherein X represents oxygen or sulfur; and n is 2 or 3). These compounds are useful as drugs, in particular, group 2 metabotropic glutamate receptor agonists, in treating and preventing psychiatric disorders such as schizophrenia, anxiety, depression and bipolar disturbance, and neurologic diseases such as drug addiction, cognition disorder, Alzheimer's disease, Huntington's disease, Parkinson's disease, movement disorder in association with muscular rigidity, brain ischemia, brain insufficiency, spinal cord lesion and head disorder.