Gibbon ape leukemia virus-based retroviral vectors

摘要

PCT No. PCT/US94/03784 Sec. 371 Date Feb. 24, 1997 Sec. 102(e) Date Feb. 24, 1997 PCT Filed Apr. 6, 1994 PCT Pub. No. WO94/23048 PCT Pub. Date Oct. 13, 1994The present invention provides replication-defective hybrid retroviral vectors comprising GaLV components and methods for preparing and using such vectors. The vectors comprise a envelope component, a core component and a defective genome, at least one of which is derived from GaLV. The vectors can comprise the minimal cis acting sequences from GaLV that allow packaging of the defective genome in a hybrid virion.