| 发明名称 |
2'-O-alkylated oligoribonucleotides and phosphorothioate analogs complementary to portions of the HIV genome |
| 摘要 |
Methods of modulating the activity of the TAR element of HIV are provided. Oligonucleotides having 6 to 50 bases and at least one 2'-O alkyl modification and selected sequences are disclosed.
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| 申请公布号 |
US6034233(A) |
申请公布日期 |
2000.03.07 |
| 申请号 |
US19910794396 |
申请日期 |
1991.11.19 |
| 申请人 |
ISIS PHARMACEUTICALS INC. |
发明人 |
ECKER, DAVID;VICKERS, TIMOTHY A. |
| 分类号 |
C07K14/16;C12N15/113;C12N15/63;C12N15/67;(IPC1-7):C07H21/00 |
主分类号 |
C07K14/16 |
| 代理机构 |
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