发明名称 |
Method for the separation of recombinant pro-factor IX from recombinant factor IX |
摘要 |
A method for separation of recombinant pro-Factor IX from recombinant Factor IX by a chromatographic method is described. According to a preferred embodiment, the mixture of both proteins is bound to an ion exchanger and pro-Factor IX and Factor IX are eluted separately from each other by buffer solutions with different salt concentrations and/or pH values. According to the method of the invention, pro-Factor IX and Factor IX are obtainable in highly pure form and free from the other factor respectively.
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申请公布号 |
US6034222(A) |
申请公布日期 |
2000.03.07 |
申请号 |
US19950538893 |
申请日期 |
1995.10.04 |
申请人 |
BIO-PRODUCTS & BIO-ENGINEERING A.G. |
发明人 |
FISCHER, BERNHARD;MITTERER, ARTUR;DORNER, FRIEDRICH;EIBL, JOHANN |
分类号 |
C12N15/09;A61K38/00;A61K38/43;A61P7/04;B01D15/08;C12N9/64;C12P21/02;C12R1/91;(IPC1-7):A61K35/14;A23J1/00 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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