发明名称 AGENT FOR EXTERNAL USE FOR SKIN
摘要 PROBLEM TO BE SOLVED: To obtain an agent for external use for skin having an inhibitory action on melanin production, excellently effective in reducing pigmentation after sunburn and in pale-coloring and whitening of blotches, freckles and chloasmata, and also good in safety. SOLUTION: This agent is obtained by including a compound of the formula (R1 is hydroxyl or methoxy; and R2 is H or methoxy), which compound is produced by either immersing the whole grass or a part of a plant, e.g. Thymus serphyllum in an adequate extraction solvent pref. at 0 to 100 deg.C for 1 to 168 hrs. or heat-refluxing the same in the extracting solvent, subjecting the extract to filtration, concentrating the filtrate, and by isolating the compound from the concentration through any proper means. The agent pref. contains 0.00001 to 10 wt.% of the compound.
申请公布号 JP2000072650(A) 申请公布日期 2000.03.07
申请号 JP19980244957 申请日期 1998.08.31
申请人 NAGASE & CO LTD 发明人 KOSAKA KUNIO;MIYAZAKI TOSHITSUGU;ITO HISATOMI;OSANAI YUKO
分类号 C07D311/30;A61K8/00;A61K8/49;A61K8/96;A61K31/35;A61K31/352;A61P17/00;A61Q19/00;A61Q19/02;(IPC1-7):A61K7/48;A61K7/00 主分类号 C07D311/30
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