Anti-CD30 antibodies preventing proteolytic cleavage and release of membrane-bound CD30 antigen

摘要

PCT No. PCT/EP96/00098 Sec. 371 Date Sep. 26, 1997 Sec. 102(e) Date Sep. 26, 1997 PCT Filed Jan. 11, 1996 PCT Pub. No. WO96/22384 PCT Pub. Date Jul. 25, 1996An antibody which binds to the CD30 antigen and a) inhibits the release of sCD30 from Hodgkin's disease cells, and b) does not bind to B cell non-Hodgkin's lymphomas or plasma cells. An example of such antibodies are the antibodies secreted from hybridoma cell line DSM ACC 2204. The antibodies may be used for diagnosis, or conjugated to a toxin to produce an immunotoxin.