| 摘要 |
A method for making a medical device having at least one biomolecule immobilized on a substrate surface is provided. The method may include combining a biomolecule comprising a 1,2 dicarbonyl moiety with a material comprising a guanidino moiety to form an immobilized biomolecule on a medical device biomaterial surface through covalent bonds. Another method of the present invention may include combining a biomolecule comprising a guanidino moiety with a material comprising a 1,2 dicarbonyl moiety to form an immobilized biomolecule on a medical device biomaterial surface through covalent bonds. Additionally, one method of the present invention may be employed to crosslink biomolecules, located in solution or on a medical device biomaterial surface, thereby forming a crosslinked biomaterial or a crosslinked medical device coating.
|
