Human stearoyl-coa desaturase-related compositions and methods for treating skin disorders

摘要

This invention provides a nucleic acid molecule encoding human stearoyl-CoA desaturase, and isolated protein encoded thereby. This invention also provides a method of diagnosing a human subject for a skin disorder characterized by an abnormal level of stearoyl-CoA desaturase expression. This invention further provides a method for determining whether an agent increases the expression level of human stearoyl-CoA desaturase in skin cells already expressing same. This invention further provides methods for determining whether an agent increases or decreases the expression level or activity of human stearoyl-CoA desaturase in skin cells already expressing same. This invention still further provides pharmaceutical compositions for treating human skin disorders characterized by abnormal stearoyl-CoA desaturase expression and/or activity, and related methods of treatment. Finally, this invention provides related antibodies, gene therapy vectors, and transgenic mice.