发明名称 |
Prodrugs of proton pump inhibitors |
摘要 |
Prodrugs of the pyridyl methyl sulfinyl benzimidazole type proton pump inhibitor drugs have a hydrolyzable arylsulfonyl or heteroarylsulfonyl group attached to the benzimidazole nitrogen. The prodrugs of the invention hydrolyze under physiological conditions to provide the proton pump inhibitors with a half life measurable in hours, and are capable of providing sustained plasma concentrations of the proton pump inhibitor drugs for longer time than presently used drugs. The generation of the proton pump inhibitor drugs from the prodrugs of the invention under physiological conditions allows for more effective treatment of several diseases and conditions caused by gastric acid secretion. |
申请公布号 |
AU5551899(A) |
申请公布日期 |
2000.03.06 |
申请号 |
AU19990055518 |
申请日期 |
1999.08.09 |
申请人 |
PARTNERSHIP OF MICHAEL E. GARST, GEORGE SACHS AND JAI MOO SHIN |
发明人 |
MICHAEL E. GARST;GEORGE SACHS;JAI MOO SHIN |
分类号 |
A61K31/4184;A61K31/4188;A61K31/437;A61K31/4427;A61K31/443;A61K31/4433;A61K31/4439;A61K31/5355;A61K31/5377;A61P1/04;A61P43/00;C07D235/28;C07D401/12;C07D401/14;C07D409/14;C07D417/14;C07D471/04;C07D495/04;C07F9/6558 |
主分类号 |
A61K31/4184 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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