Adenovirus formulations for gene therapy

摘要

The present invention relates to a formulation allowing the preservation of viral particles and viral vectors, which is directly injectable into an organism. It relates more particularly to a formulation for the preservation of a recombinant adenovirus vector that optimally enhances the vector titer, or stabilizes the vector at refrigerator or room temperature, or both. The invention relates to compositions comprising a recombinant adenovirus vector and a concentration of human serum albumin (HSA) effective to stabilize the adenovirus vector at a temperature above the freezing point of water or to enhance a titer of the adenovirus vector compared to a titer in the absence of HSA, or both, in an aqueous buffer.