发明名称 |
2-AMINO-BICYCLO[3.1.0]HEXANE-2,6-DICARBOXYLIC ACID DERIVATIVES AND A PROCESS FOR PREPARATION THEREOF |
摘要 |
The present invention relates to the compound of formulae <IMG> and to a novel process for the manufacture of compounds of the general formula <IMG> wherein T is tritium; R1 is hydroxy, lower alkoxy, lower alkenyloxy, benzyloxy, hydrogen, deuterium or tritium; R11 is hydrogen, deuterium or optionally tritium, hydroxy or amino and R2 is hydrogen or optionally tritium or R1 and R2 form a bond. Compounds of general formula I are ligands for the metabotropic glutamate receptors of group II.
|
申请公布号 |
CA2281272(A1) |
申请公布日期 |
2000.03.03 |
申请号 |
CA19992281272 |
申请日期 |
1999.08.31 |
申请人 |
F. HOFFMANN-LA ROCHE AG |
发明人 |
MUTEL, VINCENT;HUGUENIN-VIRCHAUX, PHILIPPE NICOLAS;ADAM, GEO;STADLER, HEINZ;WOLTERING, THOMAS JOHANNES |
分类号 |
A61K31/00;A61K31/196;A61P25/00;A61P25/18;C07C227/16;C07C227/32;C07C229/50;C07C247/14;(IPC1-7):C07C229/50;A61K51/00;C07C227/14;A61K31/195 |
主分类号 |
A61K31/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|