OXINDOLE DERIVATIVES AS GROWTH HORMONE RELEASERS

摘要

An oxindole of Formula (1) or a prodrug thereof, or a pharmaceutically acceptable salt thereof is useful for growth hormone releaser wherein R<1>, R<2>, R<3>, and R<4> are independently hydrogen, optionally substituted alkyl, etc; R<5> is optionally substituted aryl or optionally substituted heteroaryl; Z is -O- or -NH-; one of W<1> and W<2> is hydrogen, alkyl or -Y-CON(R<10>)R<11>; the other of W<1> and W<2> is (a); n is 1, 2 or 3; m is 0, 1, 2 or 3; Y is single bond or C1-C3 alkylene; R<6> and R<7> are independently hydrogen, optionally substituted alkyl, etc; R<8> and R<9> are independently hydrogen, optionally substituted alkyl, etc; R<10> and R<11> are independently hydrogen, alkyl etc.