| 摘要 |
<p>The invention concerns a method comprising the following steps: a) preparing a reaction medium by mixing hesperidin, iodine, pyridine and an alkaline or alkaline-earth metal base, said reaction medium being substantially water-free and the mineral base being brought in solid form; b) heating said reaction medium to obtain a reaction product containing diosmin; and c) purifying the reaction product by eliminating pyridine and iodine residues. The mineral base can be sodium hydroxide, potassium hydroxide or calcium carbonate. At the purifying step c) a further sub-step is provided for eliminating iodine-containing residues by solution in a solvent comprising a secondary amine such as morpholine. Said method ensures a residual iodine content less than 200 ppm.</p> |
