发明名称 |
METHODS TO ENHANCE AND CONFINE EXPRESSION OF GENES |
摘要 |
The present invention provides a novel approach to gene therapy of restricted areas such as tumors. The methods introduced here comprise: (a) placing a gene of interest in a plasmid vector driven by a heat or light inducible promoter; (b) modifying this vector by including a tetracycline responsive fusion protein which acts as a transcriptional activator, thus permitting regulation of gene expression by varying the levels of drug and; (c) modifying this vector by including DNA sequences that reduce or eliminate expression of genes in normal bystander cells. Also provided are a set of vectors for both sustained and regulable expression. There is also presented novel vectors for the gene therapy treatment of local and metastatic breast, ovarian and prostate cancer.
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申请公布号 |
WO0010612(A1) |
申请公布日期 |
2000.03.02 |
申请号 |
WO1999US19095 |
申请日期 |
1999.08.18 |
申请人 |
RESEARCH DEVELOPMENT FOUNDATION |
发明人 |
FUNG, YUEN, KAI;GOMER, CHARLES;T'ANG, ANNE |
分类号 |
C12N15/09;A61K35/76;A61K38/17;A61K38/19;A61K48/00;A61P35/00;C12N5/10;C12N15/63;C12N15/85;(IPC1-7):A61K48/00 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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