| 摘要 |
<p>PCT No. PCT/US93/01208 Sec. 371 Date Dec. 12, 1994 Sec. 102(e) Date Dec. 12, 1994 PCT Filed Feb. 16, 1993 PCT Pub. No. WO93/25552 PCT Pub. Date Dec. 23, 1993 <IMAGE> (1) <IMAGE> (2) <IMAGE> (3) <IMAGE> (4) <IMAGE> (5) Optically pure intermediates of formula (1) wherein the substituent B is either cis or trans to the C9a-C1 bond and is selected from the group consisting of -CH2OH, -CHO, -CH2OSO2R, -CH2CN, -CH(OH)CH2NO2, -CH=CH-NO2, (2) and (3), C is selected from the group consisting of -H, (4), (5), and a nitrogen protecting group which is removable by hydrogenation or acid treatment; and wherein R is (C1-C8) alkyl, phenyl or alkyl substituted phenyl; X is N or CH; Y is O or S and Z is H or Cl; for the synthesis of octahydro-1H-pyrido(1,2-a)pyrazinyl ethyl carboxamide anxiolytic agents.</p> |
