Verfahren zur Herstellung von 7-(3-Amino- sowie 3-Aminomethyl-1-pyrrolidinyl)-3-chinolon-carbonsäuren sowie -naphthyridoncarbonsäuren

摘要

The present invention relates to a process for the preparation of 7-(3-amino- and 3-aminomethyl-1-pyrrolidinyl)-3-quinolonecarboxylic acids and -naphthyridonecarboxylic acids of the general formula I …… in which X<1>, R<1>-R<6>, m, n and A have the meaning given in the description, which have been disclosed as antibacterial agents and are prepared by reaction of 7-halo-3-quinolonecarboxylic acids or -naphthyridonecarboxylic acids with 3-aminopyrrolidine or 3-aminomethylpyrrolidine in free form or in the form of the 3-acylamino- or 3-acylaminomethyl-pyrrolidines and subsequent removal of the acyl radicals. …The invention additionally relates to compounds of the formulae III and IV …… in which the substituents have the meaning given in the description, and to the use of IV as medicaments and for the production of medicaments.