| 发明名称 |
ASSAYS, METHODS AND MEANS FOR MODULATING NUCLEAR LOCALISATION |
| 摘要 |
CBP histone acetyltransferase acetylates Importin .alpha., affecting ability of Importin .alpha. to translocate into the nucleus and import a cargo protein. Assays identify substances which modulate interaction between CBP a nd Importin .alpha. and acetylation of Importin .alpha. by CBP. Substances identified in the assays are useful for treatment of disorders in which Importin .alpha. plays a role.
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| 申请公布号 |
CA2338837(A1) |
申请公布日期 |
2000.03.02 |
| 申请号 |
CA19992338837 |
申请日期 |
1999.08.20 |
| 申请人 |
CANCER RESEARCH CAMPAIGN TECHNOLOGY LIMITED |
发明人 |
KOUZARIDES, TONY |
| 分类号 |
G01N33/50;A61K38/00;A61K45/00;A61K48/00;A61P9/10;A61P17/06;A61P35/00;A61P43/00;C07K14/47;C12N9/10;C12N15/09;C12Q1/02;C12Q1/48;G01N33/15;G01N33/68;(IPC1-7):G01N33/68 |
主分类号 |
G01N33/50 |
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