<p>The accumulation of homoplasmic somatic mutations has been observed in the mitochondrial DNA of certain tumor cells. The presence or a recurrence of a tumor can be detected by determining the presence of single basepair mutations in the mitochondrial genome from a cell sample of a patient.</p>
申请公布号
WO0011219(A1)
申请公布日期
2000.03.02
申请号
WO1999US18775
申请日期
1999.08.20
申请人
THE JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE;VOGELSTEIN, BERT;KINZLER, KENNETH, W.;POLYAK, KORNELIA
