PEG-IFN- beta conjugates, where a PEG moiety is covalently bound to Cys<17> of human IFN- beta , are produced by a process of site specific PEGylation with a thiol reactive PEGylating agent. A pharmaceutical composition and a method for treating infections, tumors and autoimmune and inflammatory diseases are also provided. The invention further relates to a method for the stepwise attachment of PEG moieties in series to a polypeptide, and more particularly to IFN- beta .
申请公布号
WO9955377(A9)
申请公布日期
2000.03.02
申请号
WO1999US09161
申请日期
1999.04.28
申请人
APPLIED RESEARCH SYSTEMS ARS HOLDING N.V.;EL TAYAR, NABIL;ROBERTS, MICHAEL, J.;HARRIS, MILTON;SAWLIVICH, WAYNE
发明人
EL TAYAR, NABIL;ROBERTS, MICHAEL, J.;HARRIS, MILTON;SAWLIVICH, WAYNE